BDBM6863 US8815926, 101::US8815926, 295

SMILES COc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2)c2cc(Cl)cn(C)c2=O)c(OC)n1

InChI Key InChIKey=AGBSXNCBIWWLHD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6863   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandPNGBDBM6863(US8815926, 101 | US8815926, 295)
Affinity DataIC50: 0.318nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandPNGBDBM6863(US8815926, 101 | US8815926, 295)
Affinity DataIC50: 0.340nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM6863(US8815926, 101 | US8815926, 295)
Affinity DataIC50: 3.00E+3nMAssay Description:Binding affinity to human MDM4 assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandPNGBDBM6863(US8815926, 101 | US8815926, 295)
Affinity DataIC50: 0.210nMAssay Description:Binding affinity to human MDM2 assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM6863(US8815926, 101 | US8815926, 295)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human MDM4 by SRP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed