BDBM648358 acsmedchemlett.2c00502 OICR 4425A, 11

SMILES Cn1ccc2n(CC(=O)Nc3ccncc3Cl)ccc2c1=O

InChI Key InChIKey=HIQOPYVKOWIEFP-UHFFFAOYSA-N

Data  1 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 648358   

TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM648358(acsmedchemlett.2c00502 OICR 4425A, 11)
Affinity DataIC50: 1.32E+5nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM648358(acsmedchemlett.2c00502 OICR 4425A, 11)
Affinity DataKd:  1.19E+5nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer.More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM648358(acsmedchemlett.2c00502 OICR 4425A, 11)
Affinity DataKd:  9.70E+4nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer. Data...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)