BDBM643076 US20240002339, Example 13

SMILES OC(=O)c1cc(ccc1NCCc1c[nH]c2ccccc12)C(F)(F)F

InChI Key InChIKey=RWKMHYNDBBVNAX-UHFFFAOYSA-N

Data  2 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 643076   

TargetCyclin-dependent kinase 2(Human)
University of Minnesota

US Patent
LigandPNGBDBM643076(US20240002339, Example 13)
Affinity DataIC50: 1.10E+3nMAssay Description:CDK2 was thawed at room temperature and buffer exchanged using Zeba spin desalting columns. The final ITC buffer was 1×PBS, 10 mM MgCl2, and 5% glyce...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
University of Minnesota

US Patent
LigandPNGBDBM643076(US20240002339, Example 13)
Affinity DataKd:  1.90E+3nMAssay Description:Briefly, a Biacore S200 (Cytiva) at 20° C. and CM5 chips were used for binding analysis. Multi-cycle runs were used for small molecule binding analys...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
University of Minnesota

US Patent
LigandPNGBDBM643076(US20240002339, Example 13)
Affinity DataKd:  2.30E+3nMAssay Description:Inhibition of CDK2 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
University of Minnesota

US Patent
LigandPNGBDBM643076(US20240002339, Example 13)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) measured after 2 hrs by fluorescence based analys...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)