BindingDB BDBM6190 3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea::CHEMBL189584::N-(tert-Butyl)-N -[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea::Pyrido[2,3-d]pyrimidine 12

BDBM6190 3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea::CHEMBL189584::N-(tert-Butyl)-N -[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea::Pyrido[2,3-d]pyrimidine 12

SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1

InChI Key InChIKey=DXCUKNQANPLTEJ-UHFFFAOYSA-N

Data 20 IC50 3 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 6190

Vascular endothelial growth factor receptor 2(Human)
Harvard Medical School

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

EC50: 250nMAssay Description:Inhibition of VEGFR2 by cellular assayMore data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1(Human)
Celon Pharma

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 22nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1(Human)
Celon Pharma

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 22nMAssay Description:Inhibition of full length human FGFR1 expressed in baculovirus system using poly (Glu,Tyr)4:1 as substrate incubated for 10 mins in presence of [gamm...More data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 2(Human)
Harvard Medical School

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 100nMAssay Description:Inhibition of VEGFR2 (unknown origin) overexpressed in mouse NIH/ 3T3 cells incubated for 5 mins followed by stimulation with VEGF for 5 mins by immu...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1(Human)
Celon Pharma

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 22nMAssay Description:Inhibition of full length human FGFR1 expressed in baculovirus system using poly (Glu,Tyr)4:1 as substrate incubated for 10 mins in presence of [gamm...More data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 2(Human)
Harvard Medical School

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 100nMAssay Description:Inhibition of VEGFR2 (unknown origin) overexpressed in mouse NIH/ 3T3 cells incubated for 5 mins followed by stimulation with VEGF for 5 mins by immu...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1(Human)
Celon Pharma

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 22nMAssay Description:Inhibition of recombinant full length human FGFR1 expressed in baculovirus infected insect cells in presence of [gamma-32P]ATP after 10 mins by scint...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 5nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase Src(Human)
Harvard Medical School

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 2.00E+4nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair

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Insulin receptor(Human)
Harvard Medical School

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 5.00E+4nMAssay Description:Inhibition of InsRMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Human)
Harvard Medical School

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 5.00E+4nMAssay Description:Inhibition of EGFR by cellular assayMore data for this Ligand-Target Pair

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Fibroblast growth factor receptor 3(Human)
Harvard Medical School

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

EC50: 30nMAssay Description:Inhibition of FGFR3 by cellular assayMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor beta(Mouse)
University of Auckland

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 1.40E+4nMAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1(Human)
Celon Pharma

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

EC50: 21nMAssay Description:Inhibition of FGFR1 by cellular assayMore data for this Ligand-Target Pair

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Tyrosine-protein kinase CSK(Human)
University of Oxford

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 1.98E+4nMAssay Description:Inhibition of cSrcMore data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1(Human)
Celon Pharma

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 22nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair

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Dual specificity mitogen-activated protein kinase kinase 1(Human)
Astrazeneca

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 5.00E+4nMAssay Description:Inhibition of MEK1 fused with GST by autoradiographyMore data for this Ligand-Target Pair

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Insulin receptor(Human)
Harvard Medical School

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 5.00E+4nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1(Human)
Celon Pharma

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 30nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair

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Serine-protein kinase ATM(Human)
University of Oxford

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 1.76E+4nMAssay Description:Inhibition of ATMMore data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 2(Human)
Harvard Medical School

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 120nMAssay Description:Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...More data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase Src(Human)
Harvard Medical School

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 2.00E+4nMAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1(Human)
Celon Pharma

Curated by ChEMBL

PNG

BDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)

IC50: 28nMAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair

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Filter my 23 hits

Targets 11▿
- Fibroblast growth factor receptor 1 8
- Vascular endothelial growth factor receptor 2 4
- Proto-oncogene tyrosine-protein kinase Src 2
- Insulin receptor 2
- Serine-protein kinase ATM 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Platelet-derived growth factor receptor beta 1
- Tyrosine-protein kinase CSK 1
- Fibroblast growth factor receptor 2 1
- Epidermal growth factor receptor 1
- Fibroblast growth factor receptor 3 1
Publications 7▿
- Proc Natl Acad Sci U S A 104: 19936-41 (2007) 7
- J Med Chem 48: 4628-53 (2005) 4
- ACS Med Chem Lett 7: 629-34 (2016) 4
- Proc Natl Acad Sci U S A 104: 20523-8 (2007) 3
- J Med Chem 55: 5003-12 (2012) 2
- Eur J Med Chem 126: 476-490 (2017) 2
- Eur J Med Chem 210: (2021) 1
Institutions 7▿
- Harvard Medical School 7
- University of Auckland 4
- Shanghai Institute of Materia Medica 4
- University of Oxford 3
- Astrazeneca 2
- The First Affiliated Hospital of Zhengzhou University 2
- Celon Pharma 1
Affinity: 5 to 5.0E+4 nM▿
- IC50 20
- EC50 3
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1