BDBM610463 BDBM610464::BDBM610465::N-(4-(2-Methylmorpholino)pyridin-3-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide::US10774086, Example 14
SMILES CC1CN(CCO1)c1ccncc1NC(=O)c1ccnn2cc(nc12)-c1ccccc1
InChI Key InChIKey=MENVSADYTLLXLP-UHFFFAOYSA-N
Data 42 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 42 hits for monomerid = 610463
TargetTyrosine-protein kinase SYK(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CK2A1 (unknown origin)More data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha'(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CK2A2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of LynA (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
TargetAurora kinase B(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 4 group A member 3(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase TXK(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cKIT (unknown origin)More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
TargetAurora kinase A(Mouse)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of mouse AURAMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MK2 (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-1(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9.20nMAssay Description:Inhibition of Tau (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Affinity DataIC50: 9.20nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Affinity DataIC50: 86nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.75nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of tau 4R1N phosphorylation (unknown origin) at S396 residue transfected in human U2OS cells coexpressing GFP-tagged beta catenin incubate...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
TargetAP2-associated protein kinase 1(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
TargetProtein kinase C theta type(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of PKCtheta (unknown origin)More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 1(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of IRAK1 (unknown origin)More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Human)
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research and Development Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair