BDBM572233 (6S)-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)- 1,8-diazaspiro[5.5]undecane::US11447505, Example E117::US11447505, Example E168

SMILES C1CCC2(CCCN(C2)c2ccnc3[nH]cc(-c4ccncn4)c23)NC1

InChI Key InChIKey=UELSMLDRSQFVHG-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 572233   

TargetSerine/threonine-protein kinase MRCK alpha(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572233(US11447505, Example E168 | (6S)-8-(3-pyrimidin-4-y...)
Affinity DataKi:  0.0140nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MRCK beta(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572233(US11447505, Example E168 | (6S)-8-(3-pyrimidin-4-y...)
Affinity DataKi:  0.0230nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase MRCK beta(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572233(US11447505, Example E168 | (6S)-8-(3-pyrimidin-4-y...)
Affinity DataKi:  0.0650nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572233(US11447505, Example E168 | (6S)-8-(3-pyrimidin-4-y...)
Affinity DataKi:  5.38nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572233(US11447505, Example E168 | (6S)-8-(3-pyrimidin-4-y...)
Affinity DataKi:  18.4nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572233(US11447505, Example E168 | (6S)-8-(3-pyrimidin-4-y...)
Affinity DataKi:  30.9nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572233(US11447505, Example E168 | (6S)-8-(3-pyrimidin-4-y...)
Affinity DataKi:  89nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent