BDBM50613392 CHEMBL5270581

SMILES O=C(Nc1cc(ccn1)C(=O)Nc1cnccc1-c1ccccc1)C1CC1

InChI Key InChIKey=LJUDIYPNWBIDNH-UHFFFAOYSA-N

Data  37 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50613392   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of IRAK4 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cKIT (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of wild type ABL (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK5/p25 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TYK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 8(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JNK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of LCK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JAK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCasein kinase II subunit alpha'(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CK2A2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase A(Mouse)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of mouse Aurora kinase A by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase B(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Aurora-B (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of BTK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human ERG by flux assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 4B1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 320nMAssay Description:Inhibition of GSK-3beta (unknown origin) assessed as decrease in tau phosphorylation by high content cell based assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of GST tagged GSK-3beta (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TRKA (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein kinase C theta type(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKC theta type (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of RSK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase SYK(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SYK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of FMS (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JAK3 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRho-associated protein kinase 1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ROCK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ROCK2 mutant (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Srms(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SRMS (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PIM1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TRKB (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TYK2 (0 to 887 residues) (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of IKK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JAK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGolgi-associated PDZ and coiled-coil motif-containing protein(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CAL (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDGFRB (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 14(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MAPK14 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed