BDBM50612273 BALOXAVIR::Baloxavir::S-033447

SMILES [H][C@@]12COCCN1C(=O)c1c(O)c(=O)ccn1N2[C@@H]1c2ccccc2SCc2c(F)c(F)ccc12

InChI Key InChIKey=FIDLLEYNNRGVFR-UHFFFAOYSA-N

Data  6 IC50  1 Kd  2 EC50

PDB links: 10 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50612273   

TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
South China Agricultural University

Curated by ChEMBL
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of N-terminal His-tagged Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) using [3H]acetyl-coA after 25 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
South China Agricultural University

Curated by ChEMBL
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447)
Affinity DataKd:  208nMAssay Description:Inhibition of Escherichia coli FabH expressed in Escherichia coli DH10B cells assessed as incorporation of 3H signal in the product after 25 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
South China Agricultural University

Curated by ChEMBL
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of Escherichia coli FabH expressed in Escherichia coli DH10B cells assessed as incorporation of 3H signal in the product after 25 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
South China Agricultural University

Curated by ChEMBL
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447)
Affinity DataIC50: 8.16E+3nMAssay Description:Inhibition of Escherichia coli FabH expressed in Escherichia coli DH10B cells assessed as incorporation of 3H signal in the product after 25 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
South China Agricultural University

Curated by ChEMBL
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of Influenza A virus CENMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447)
Affinity DataIC50: 1.14nMMore data for this Ligand-Target Pair
In DepthDetails
PDB3D3D Structure (crystal)
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447)
Affinity DataEC50:  0.680nMMore data for this Ligand-Target Pair
In DepthDetails
PDB3D3D Structure (crystal)
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447)
Affinity DataIC50: 2.01nMMore data for this Ligand-Target Pair
In DepthDetails
PDB3D3D Structure (crystal)
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447)
Affinity DataEC50:  1.22nMMore data for this Ligand-Target Pair
In DepthDetails
PDB3D3D Structure (crystal)