BDBM50611058 CHEMBL5279050

SMILES CC1(C)CCN(Cc2ccc(C(=O)NC[C@]3(O)CCCN(C3)c3cc(NCc4ccccc4)ncn3)c(O)c2)CC1

InChI Key InChIKey=PWYRDVXYAOGDNK-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50611058   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50611058(CHEMBL5279050)
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant METTL3 (354 to 580 residues)/METTL14 (106 to 396 residues) (unknown origin) using m6A oligonucleotide as substrate by HTRF ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Yunnan University

Curated by ChEMBL
LigandPNGBDBM50611058(CHEMBL5279050)
Affinity DataIC50: 280nMAssay Description:Inhibition of METTL3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Yunnan University

Curated by ChEMBL
LigandPNGBDBM50611058(CHEMBL5279050)
Affinity DataIC50: 17nMAssay Description:Inhibition of METTL3 in human MOLM-13 cells assessed as reduction in m6A methylation levelMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)