BDBM50606613 CHEMBL5219865

SMILES O[C@@H]1CCCC[C@H]1CNc1cc(Br)cc2[nH]ncc12

InChI Key InChIKey=KBSUKSFOQICUON-UHFFFAOYSA-N

Data  3 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50606613   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50606613(CHEMBL5219865)
Affinity DataIC50: 640nMAssay Description:Inhibition of human IDO1 (12 to 403 aa) expressed in Escherichia coli Transetta (DE3) by nanodrop 2000c spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTryptophan 2,3-dioxygenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50606613(CHEMBL5219865)
Affinity DataIC50: 40nMAssay Description:Inhibition of human TDO (19 to 388 aa) expressed in Escherichia coli Transetta (DE3) by nanodrop 2000c spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50606613(CHEMBL5219865)
Affinity DataEC50:  5.50E+3nMAssay Description:Inhibition of IDO1 in IFN-gamma induced overexpressing human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTryptophan 2,3-dioxygenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50606613(CHEMBL5219865)
Affinity DataEC50:  1.07E+3nMAssay Description:Inhibition of TDO in overexpressing human SW48 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50606613(CHEMBL5219865)
Affinity DataEC50:  3.03E+3nMAssay Description:Inhibition of TDO in overexpressing human A-172 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2C9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50606613(CHEMBL5219865)
Affinity DataIC50: 9.27E+3nMAssay Description:Inhibition of human liver microsome CYP2C9 using 4'-hydroxy diclofenac as substrate incubated for 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed