BDBM50605537 CHEMBL5183988

SMILES [H][C@]12CN([C@H](C)CN1c1ncnc3c(F)c(c(Cl)c(OCC2)c13)-c1c(O)cccc1F)C(=O)C=C

InChI Key InChIKey=KYVBBJIEKCCZTM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50605537   

TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605537(CHEMBL5183988)
Affinity DataIC50: 3nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605537(CHEMBL5183988)
Affinity DataIC50: 36nMAssay Description:Inhibition of p90RSK phosphorylation in human NCI-H358 cells harboring KRAS G12C mutant measured for 2 hrs by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605537(CHEMBL5183988)
Affinity DataIC50: 4.95E+3nMAssay Description:Inhibition of p90RSK phosphorylation in human PC-9 cells measured for 2 hrs by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605537(CHEMBL5183988)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of p90RSK phosphorylation in human Calu-6 cells harboring KRAS Q61K measured for 2 hrs by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed