BDBM50598015 CHEMBL5199380

SMILES COC(=O)c1cc(O)c2cc(NC(=O)NCCCNC(=N)NC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)ccc2c1

InChI Key InChIKey=GJPQENHVEQGHGP-UHFFFAOYSA-N

Data  8 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50598015   

TargetProtein arginine N-methyltransferase 1(Human)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598015(CHEMBL5199380)
Affinity DataIC50: 3.23E+4nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598015(CHEMBL5199380)
Affinity DataIC50: 5.72E+4nMAssay Description:Inhibition of human full length recombinant GST his-tagged PRMT3 (2 to 531 residues) using histone H4 as substrate incubated for 20 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598015(CHEMBL5199380)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598015(CHEMBL5199380)
Affinity DataIC50: 5.21E+4nMAssay Description:Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598015(CHEMBL5199380)
Affinity DataIC50: 7.28E+4nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT6 (2 to 375 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 7(Human)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598015(CHEMBL5199380)
Affinity DataIC50: 320nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598015(CHEMBL5199380)
Affinity DataIC50: 8.29E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598015(CHEMBL5199380)
Affinity DataKd:  663nMAssay Description:Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as dissociation constant by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 9(Homo sapiens)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50598015(CHEMBL5199380)
Affinity DataIC50: 890nMAssay Description:Inhibition of human recombinant PRMT9 using biotinylated SF3B2(500 to 519 residues) as substrate and SAM as cosubstrate pre-incubated with compound f...More data for this Ligand-Target Pair
In DepthDetails
PubMed