BDBM50594741 CHEMBL5205088
SMILES C[C@H]1CN(Cc2cc(Cl)cc(NC(=O)c3cnc(C)nc3)c2C)CCN1C(=O)C1CCCC1
InChI Key InChIKey=HAXBJJXPLDXDIL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50594741
Affinity DataIC50: 1nMAssay Description:Inverse agonist activity at recombinant 6His-tagged human RORgamma LBD (264 to 518 residues) assessed as inhibition of biotinylated RIP140 co-activat...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at recombinant Gal4-fused human RORgammat LBD expressed in Jurkat cells assessed as luciferase activity measured after 24 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inverse agonist activity against human RORgammat assessed as IL-17 secretion incubated for 72 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inverse agonist activity at His tagged human RORgammat incubated for 1 hrs in presence of biotinylated co-activator peptide by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at human RORgammat LBD expressed in Jurkat cells incubated for 24 hrs by Gal4 luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity against human RORgammat assessed as IL-17 secretion by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human RORgammat expressed in COS7 cells by luciferase assayMore data for this Ligand-Target Pair