BDBM50594406 EZM-0414::EZM0414::Ezm-0414

SMILES CC(=O)N1CCN(CC1)[C@H]1CCC[C@H](C1)NC(=O)c1cc2c(F)ccc(C)c2[nH]1

InChI Key InChIKey=PGNLXEBQMQHFNK-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50594406   

TargetHistone-lysine N-methyltransferase SETD2(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50594406(EZM-0414 | Ezm-0414 | EZM0414)
Affinity DataIC50: 18nMAssay Description:Inhibition of SETD2 (1434 to 1711 residues) (unknown origin) using SAM and biotin-Ahx-RKSAPATGGVKKPHR-NH2 as substrate preincubated for 30 mins follo...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SETD2(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50594406(EZM-0414 | Ezm-0414 | EZM0414)
Affinity DataIC50: 31nMAssay Description:Inhibition of SETD2 in human A549 cells assessed as reduction in H3K36me3 incubated for 3 days by in-cell western assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2C8(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50594406(EZM-0414 | Ezm-0414 | EZM0414)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 5 mins followed by NADPH addition measured after 10 min...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 1A2(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50594406(EZM-0414 | Ezm-0414 | EZM0414)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 5 mins followed by NADPH addition measured after 20 min...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2B6(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50594406(EZM-0414 | Ezm-0414 | EZM0414)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2C9(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50594406(EZM-0414 | Ezm-0414 | EZM0414)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2C19(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50594406(EZM-0414 | Ezm-0414 | EZM0414)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (s)-mephenytoin as substrate preincubated for 5 mins followed by NADPH addition measured after ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2D6(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50594406(EZM-0414 | Ezm-0414 | EZM0414)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins followed by NADPH addition measured after ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 3A4(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50594406(EZM-0414 | Ezm-0414 | EZM0414)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(2) dopamine receptor(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50594406(EZM-0414 | Ezm-0414 | EZM0414)
Affinity DataIC50: 1.30E+4nMAssay Description:Antagonist activity at D2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50594406(EZM-0414 | Ezm-0414 | EZM0414)
Affinity DataIC50: 3.20E+3nMAssay Description:Agonist activity at 5-HT1B receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed