BDBM50593687 CHEMBL5184305

SMILES COC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1nc(Nc2cnn(C)c2)nc2ccn(CC#N)c(=O)c12

InChI Key InChIKey=HGLZLKIEOLRRSD-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50593687   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50593687(CHEMBL5184305)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant IRAK4 assessed as unphosphorylated KKARFSRFAGSSPSQSSMVAR peptide substrate measured after 2 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50593687(CHEMBL5184305)
Affinity DataIC50: 440nMAssay Description:Inhibition of IRAK4 in IL1-stimulated human KARPAS-299 cells assessed as fluorescence intensityMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)