BDBM50593633 ARQ 092::ARQ 092 FREE BASE::ARQ-092::Arq-092::MIRANSERTIB::Miransertib

SMILES Nc1ncccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1ccccc1

InChI Key InChIKey=HNFMVVHMKGFCMB-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50593633   

LigandPNGBDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 5nMAssay Description:Inhibition of AKT (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of AKT1 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of AKT2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of AKT3 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 5nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of AKT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 16nMAssay Description:Inhibition of AKT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed