BDBM50591155 CHEMBL5183718::US20240034730, Compound 36

SMILES CC(C)c1cc(Oc2ccncc2)c(C)cc1NC(=O)c1c(O)nn2ccccc12

InChI Key InChIKey=IGBISIGCTJJXOY-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50591155   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50591155(CHEMBL5183718 | US20240034730, Compound 36)
Affinity DataIC50: 70nMAssay Description:Inhibition of human N-terminal GST-fusion tagged DHODH (31 to 395 residues) expressed in Escherichia coli BL21-GOLD (DE3) using dihydroorotate as sub...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50591155(CHEMBL5183718 | US20240034730, Compound 36)
Affinity DataIC50: 70nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)