BDBM50587871 CHEMBL5176610

SMILES Cc1cc(ccc1O)-c1ccnc2cc(O)ccc12

InChI Key InChIKey=QXFYDRYRLOHSBD-UHFFFAOYSA-N

Data  3 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50587871   

TargetToll-like receptor 8(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587871(CHEMBL5176610)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at R848 stimulated TRL8 overexpressed in HEK293 cells measured after 20 to 24 hrs by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587871(CHEMBL5176610)
Affinity DataKd:  21nMAssay Description:Binding affinity to human TLR8 expressed in HEK-Blue hTLR8 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587871(CHEMBL5176610)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human TLR8More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587871(CHEMBL5176610)
Affinity DataKd:  21nMAssay Description:Antagonist activity at human TLR8 by Isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587871(CHEMBL5176610)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human TLR8 stably expressed in human HEK-Blue hTLR8 cells incubated for 24 hrs by Quanti-Blue based SEAP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)