BDBM50586946 CHEMBL5084336

SMILES Fc1cccc(Cn2ccc3cc(ccc23)C(=O)NCc2ccc(NS(=O)(=O)C3CC3)cc2C(F)(F)F)c1

InChI Key InChIKey=NONHTXRHOREFAH-UHFFFAOYSA-N

Data  2 IC50  2 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50586946   

TargetBifunctional epoxide hydrolase 2(Human)
Goethe-University

Curated by ChEMBL
LigandPNGBDBM50586946(CHEMBL5084336)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University

Curated by ChEMBL
LigandPNGBDBM50586946(CHEMBL5084336)
Affinity DataEC50:  220nMAssay Description:Partial agonist activity at GAL4-tagged human PPARgamma LBD expressed in HEK293T cells incubated for 12 to 14 hrs by dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Mouse)
Goethe-University

Curated by ChEMBL
LigandPNGBDBM50586946(CHEMBL5084336)
Affinity DataIC50: 202nMAssay Description:Inhibition of N-terminal His-tagged mouse sEH (2 to 554 residues) expressed in Escherichia coli Rosetta2 (DE3) assessed as reduction in 6-methoxy-2-n...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University

Curated by ChEMBL
LigandPNGBDBM50586946(CHEMBL5084336)
Affinity DataEC50:  180nMAssay Description:Partial agonist activity at sGSF-PPARgamma (unknown origin) assessed as CBP-1 recruitment by HT-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)