BDBM50586498 CHEMBL5077332::US20240139189, Compound 22

SMILES CNc1cc(ncn1)N1CCC2(CC1)CN(CC(=O)N2)c1cc(F)c(CN2CCC(C)(C)CC2)cc1F

InChI Key InChIKey=GYWOVBUGFWWSJR-UHFFFAOYSA-N

Data  2 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50586498   

TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50586498(CHEMBL5077332 | US20240139189, Compound 22)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant METLL3 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in N6-methyladenosine level in oli...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50586498(CHEMBL5077332 | US20240139189, Compound 22)
Affinity DataEC50:  2.00E+3nMAssay Description:Thermal stabilization of recombinant METTL3 (354 to 580 residues) (unknown origin) expressed in HEK293T cells assessed as non-aggregated METTL3-ePL p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50586498(CHEMBL5077332 | US20240139189, Compound 22)
Affinity DataEC50:  850nMAssay Description:Thermal stabilization of endogenously expressing full length METTL3 in human MOLM-13 cells assessed as stabilized METTL3 incubated for at 54 degC by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetN6-adenosine-methyltransferase non-catalytic subunit(Human)
University of Zurich

US Patent
LigandPNGBDBM50586498(CHEMBL5077332 | US20240139189, Compound 22)
Affinity DataIC50: 8nMAssay Description:No details are given in this patent.More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)