BDBM50585526 CHEMBL5084809

SMILES CC(=O)N1CCC(CC1)Nc1cccc2cnc(Nc3cnn(C)c3)nc12

InChI Key InChIKey=MYAXOPAVZLMPET-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50585526   

TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585526(CHEMBL5084809)
Affinity DataIC50: 126nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585526(CHEMBL5084809)
Affinity DataIC50: 32nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585526(CHEMBL5084809)
Affinity DataIC50: 50nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50585526(CHEMBL5084809)
Affinity DataIC50: 100nMAssay Description:Inhibition of human TYK2 (888 to 1178 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed