BDBM50582522 CHEMBL5092444

SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2CO[P@](S)(=O)O[C@H]3C[C@@H](C[C@@H]3CO[P@](S)(=O)O[C@@H]1[C@@H]2O)Nc1ccncn1

InChI Key InChIKey=DXJHOSYLPZBMEZ-UHFFFAOYSA-N

Data  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50582522   

TargetStimulator of interferon genes protein(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM50582522(CHEMBL5092444)
Affinity DataEC50:  85nMAssay Description:Binding affinity to human STING incubated for 60 mins measured by competitive TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM50582522(CHEMBL5092444)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at STING KO human THP-1 dual cells incubated for 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Mouse)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM50582522(CHEMBL5092444)
Affinity DataEC50:  700nMAssay Description:Agonist activity at mouse STING in THP-1 dual cells incubated for 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStimulator of interferon genes protein(Mouse)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM50582522(CHEMBL5092444)
Affinity DataEC50:  500nMAssay Description:Agonist activity at STING in mouse RAW264.7 cells incubated for 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed