BDBM50579856 CHEMBL5083976

SMILES COc1cccc(c1)-c1nccc(n1)-c1cc2c([nH]1)C1(CCN(CC1)C(=O)C=C)CNC2=O

InChI Key InChIKey=XYZWQPFTGADMOX-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50579856   

TargetEpidermal growth factor receptor(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50579856(CHEMBL5083976)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) preincubated for 60 mins followed by substrate addition and further incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50579856(CHEMBL5083976)
Affinity DataIC50: 32nMAssay Description:Inhibition of wild type EGFR (unknown origin) preincubated for 60 mins followed by substrate addition and further incubated for 60 mins in presence o...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50579856(CHEMBL5083976)
Affinity DataEC50:  2.55E+3nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed