BDBM50574225 CHEMBL4850857

SMILES Cc1cc(Br)c(CNc2ncc(C(=O)NCCCN3CCOC3=O)c(NC3CCCC3)n2)cc1Br

InChI Key InChIKey=BPLPIBNWDLPUKP-UHFFFAOYSA-N

Data  1 KI  6 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50574225   

TargetPeripheral plasma membrane protein CASK(Human)
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50574225(CHEMBL4850857)
Affinity DataKd:  22nMAssay Description:Binding affinity to recombinant N-terminal His-tagged CASK (1 to 337 residues) (unknown origin) expressed in Escherichia coli assessed as dissociatio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPeripheral plasma membrane protein CASK(Human)
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50574225(CHEMBL4850857)
Affinity DataIC50: 80nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused CASK (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase receptor TYRO3(Human)
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50574225(CHEMBL4850857)
Affinity DataIC50: 3.79E+3nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused TYRO3 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50574225(CHEMBL4850857)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused MERTK (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50574225(CHEMBL4850857)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused AXL (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50574225(CHEMBL4850857)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused ABL1 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50574225(CHEMBL4850857)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused CSNK1E (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeripheral plasma membrane protein CASK(Human)
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50574225(CHEMBL4850857)
Affinity DataKi:  11nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused CASK (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)