BDBM50571811 CHEMBL4856564

SMILES COc1ccc(cc1)S(=O)(=O)N(CC(N)=O)c1ccc(N(CC(N)=O)S(=O)(=O)c2ccc(N)cc2)c2ccccc12

InChI Key InChIKey=DFIZGWXPFCOCFG-UHFFFAOYSA-N

Data  1 KI  3 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50571811   

TargetNuclear factor erythroid 2-related factor 2(Human)
Ningxia Medical University

Curated by ChEMBL
LigandPNGBDBM50571811(CHEMBL4856564)
Affinity DataKd:  212nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) interaction measured after 60 mins by Fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Ningxia Medical University

Curated by ChEMBL
LigandPNGBDBM50571811(CHEMBL4856564)
Affinity DataKd:  230nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged human KEAP1 Kelch domain (322 to 609 residues) expressed in Escherichia coli BL21 (DE3) by flu...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
Ningxia Medical University

Curated by ChEMBL
LigandPNGBDBM50571811(CHEMBL4856564)
Affinity DataKd:  230nMAssay Description:Inhibition of recombinant N-terminal His6-tagged human Keap1-Nrf2 (322 to 609 residues) (unknown origin) protein-protein interaction expressed in Esc...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
Ningxia Medical University

Curated by ChEMBL
LigandPNGBDBM50571811(CHEMBL4856564)
Affinity DataKi:  95nMAssay Description:Inhibition of Keap1 (unknown origin)/Nrf2 (unknown origin) protein-protein interaction assessed as inhibition constant by fluorescence anisotropy ass...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)