BDBM50569640 CHEMBL4861270

SMILES CCCC[C@H](NC(=O)[C@H](C)c1c(C)[nH]c2ccc(O)cc12)c1ncc([nH]1)-c1cc2ccccc2nc1OC

InChI Key InChIKey=CZYALTGXIQQGCT-UHFFFAOYSA-N

Data  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50569640   

TargetHistone deacetylase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC1 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50: 87nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC2 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50: 240nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataEC50:  1.90E+3nMAssay Description:Activation of PXR (unknown origin) expressed in human DPX2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as induction...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as reduction in 4'-hydroxy diclofenac level using diclofenac as substrate incubated for 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of class 1 HDAC in quiescent human primary T-cell model of VSV-G pseudotyped HIV-1 latency assessed as reactivation of HIV latency incubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed