BDBM50568726 CHEMBL4854181

SMILES Cc1[nH]c(C(=O)Nc2nc3c(OCc4ccccc4)cc(cc3s2)C(O)=O)c(Cl)c1Cl

InChI Key InChIKey=QJJVAUMJKWWKTD-UHFFFAOYSA-N

Data  9 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50568726   

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568726(CHEMBL4854181)
Affinity DataIC50: 10nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568726(CHEMBL4854181)
Affinity DataIC50: 16nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568726(CHEMBL4854181)
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of human topoisomerase II alphaMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568726(CHEMBL4854181)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568726(CHEMBL4854181)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of Escherichia coli DNA gyrase incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDNA gyrase subunit B(Escherichia coli)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568726(CHEMBL4854181)
Affinity DataIC50: 10nMAssay Description:Inhibition of Escherichia coli full length wildtype GyrB24 (residue 1 to 220) supercoiling in presence of pNO1 plasmid incubated for 30 mins by micro...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetDNA gyrase subunit B(Escherichia coli)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568726(CHEMBL4854181)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Escherichia coli full length wildtype GyrB24 (residue 1 to 220) assessed as ATP-independent relaxation for 2 hrs in presence of pBR322 ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A4(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568726(CHEMBL4854181)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568726(CHEMBL4854181)
Affinity DataIC50: 10nMAssay Description:Inhibition of Escherichia coli DNA gyrase supercoilingMore data for this Ligand-Target Pair
In DepthDetails
PubMed