BDBM50561817 CHEMBL4595238

SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H](CN2CCCC22CCNCC2)[C@@H](O)[C@H]1O

InChI Key InChIKey=RERIOYBALRXMSF-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50561817   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561817(CHEMBL4595238)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561817(CHEMBL4595238)
Affinity DataIC50: 58nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in arginine dimethylation of SmD1/3 after 48 hrs by Hoechst Stain/ CellMask Deep Red St...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)