BDBM50561218 CHEMBL4785716::US11377469, Example 10

SMILES O[C@@H]1[C@@H](COCP(O)(O)=O)O[C@H]([C@@H]1O)n1ncc2c(NCc3ccccc3Cl)nc(Cl)nc12

InChI Key InChIKey=VAGWGCSOWAKFTM-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50561218   

Target5'-nucleotidase(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561218(CHEMBL4785716 | US11377469, Example 10)
Affinity DataIC50: 29nMAssay Description:Inhibition of human C-terminal His6-tagged CD73 expressed in CHO cells preincubated for 15 mins followed by AMP addition and measured after 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561218(CHEMBL4785716 | US11377469, Example 10)
Affinity DataIC50: 500nMAssay Description:Assay Reaction ConditionsAssay Volume: 70 μlReaction Volume: 50 μlCD73: 0.3208 nMAMP: 15 μMAssay Buffer: 2 5 mM Tris-HCL, pH 7.4, 0.01...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)