BDBM50557929 CHEMBL4755144

SMILES COc1ccc(Cl)cc1NC(=O)Nc1ccc2nc(NC(=O)c3ccccc3)sc2c1

InChI Key InChIKey=GFYCKNKAOMHFQF-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50557929   

LigandPNGBDBM50557929(CHEMBL4755144)
Affinity DataIC50: 178nMAssay Description:Inhibition of human TRKA kinase domain by HTRF KinEASE biochemical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50557929(CHEMBL4755144)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human TRKA by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBDNF/NT-3 growth factors receptor(Human)
Zoetis

Curated by ChEMBL
LigandPNGBDBM50557929(CHEMBL4755144)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human TRKB by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50557929(CHEMBL4755144)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TRKA at inactive state assessed as inhibition of substrate phosphorylation using fluorescently-labelled peptide as substrate by c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50557929(CHEMBL4755144)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TRKA at active state assessed as inhibition of substrate phosphorylation using fluorescently-labelled peptide as substrate by cal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)