BDBM50553783 Ptpn11 inhibitor tno155::Shp2 inhibitor tno155::Tno-155::Tno155::US12053470, Compound 16::US20240270753, Compound TNO155

SMILES C[C@@H]1OCC2(CCN(CC2)c2cnc(Sc3ccnc(N)c3Cl)c(N)n2)[C@@H]1N

InChI Key InChIKey=UCJZOKGUEJUNIO-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50553783   

LigandPNGBDBM50553783(Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | ...)
Affinity DataIC50: 11nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50553783(Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | ...)
Affinity DataIC50: 11nMAssay Description:Allosteric inhibition of human SHP2 in human KYSE-520 cells assessed as reduction in ERK1/2 phosphorylation by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50553783(Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50553783(Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | ...)
Affinity DataIC50: 11nMAssay Description:Allosteric inhibition of wild-type human SHP2 (1 to 535 residues) using DiFMUP and 2p-IRS1 peptide as substrates preincubated for 1 hr and followed b...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50553783(Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | ...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of SHP2 (unknown origin) using DiFMUP as substrate incubated for 60 mins followed by substrate addition for 30 mins by microplate reader m...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50553783(Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | ...)
Affinity DataIC50: 10nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50553783(Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | ...)
Affinity DataIC50: 10nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50553783(Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | ...)
Affinity DataIC50: 11nMAssay Description:Inhibition of SHP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50553783(Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | ...)
Affinity DataIC50: 9nMAssay Description:(a) The positive control SHP099 was prepared according to the reported literature (J Med Chem 2016, 59 (17), 7773-82); and the positive control TNO15...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)