BDBM50550246 PF06273340::Pf-06273340

SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnc(N)nc12

InChI Key InChIKey=BPIWZDNVMQQBQX-UHFFFAOYSA-N

Data  1 KI  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50550246   

LigandPNGBDBM50550246(Pf-06273340 | PF06273340)
Affinity DataIC50: 6nMAssay Description:Inhibition of human TrkA expressed in human U2OS cells pre-incubated 30 mins before neurotrophin addition and measured after 2 hrs by luminescence ba...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
TargetBDNF/NT-3 growth factors receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50550246(Pf-06273340 | PF06273340)
Affinity DataIC50: 4nMAssay Description:Inhibition of human TrkB expressed in human U2OS cells pre-incubated 30 mins before neurotrophin addition and measured after 2 hrs by luminescence ba...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50550246(Pf-06273340 | PF06273340)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TrkC expressed in human U2OS cells pre-incubated 30 mins before neurotrophin addition and measured after 2 hrs by luminescence ba...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50550246(Pf-06273340 | PF06273340)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50550246(Pf-06273340 | PF06273340)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50550246(Pf-06273340 | PF06273340)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of dopamine transporter (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50550246(Pf-06273340 | PF06273340)
Affinity DataIC50: 53nMAssay Description:Inhibition of MUSK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50550246(Pf-06273340 | PF06273340)
Affinity DataIC50: 53nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50550246(Pf-06273340 | PF06273340)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of IRAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50550246(Pf-06273340 | PF06273340)
Affinity DataKi: >4.03E+4nMAssay Description:Inhibition of dofetilide binding to human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed