BDBM50549954 CHEMBL4791380::US11505536, Example 11

SMILES CCn1c(CO)nn(-c2cc3c(cn(-c4c(F)cccc4Cl)c(=O)c3cc2F)C(C)C)c1=O

InChI Key InChIKey=JIAAFQOLGVGLEY-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50549954   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50549954(CHEMBL4791380 | US11505536, Example 11)
Affinity DataIC50: 0.222nMAssay Description:Inhibition of human DHODH (30 to 390 residues) expressed in Escherichia coli using dihydroorotate as substrate and CoQ10 as co-substrate by DCIP dye ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50549954(CHEMBL4791380 | US11505536, Example 11)
Affinity DataIC50: 0.222nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)