BDBM50534274 CHEMBL4457557

SMILES NC(=O)c1ccc(Cc2ccccc2)cc1-c1cccc(CCC(O)=O)c1

InChI Key InChIKey=UHEGDWIZAOPGIY-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50534274   

TargetCytochrome P450 2D6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 3.33E+4nMAssay Description:Inhibition of human Nav1.5 expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 3.33E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGroup 10 secretory phospholipase A2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant sPLA2-10 (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2, membrane associated(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 3.33E+4nMAssay Description:Inhibition of human Kv4.3 expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C8(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human OATP1B1 expressed in HEK293 cells assessed as reduction in pivastatin uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 3.33E+4nMAssay Description:Inhibition of human Cav1.2 expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50: 3.33E+4nMAssay Description:Inhibition of human Cav3.2 expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed