BDBM50533571 CHEMBL1618254::US11459295, Compound R-Naproxen (1a)

SMILES COc1ccc2cc(ccc2c1)[C@@H](C)C(O)=O

InChI Key InChIKey=CMWTZPSULFXXJA-UHFFFAOYSA-N

Data  1 KI  9 IC50  2 EC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50533571   

TargetAldo-keto reductase family 1 member C3(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX1 in ram seminal vesicles using arachidonic acid as substrate assessed as reduction in PGH2 conversion to PGG2 by measuring TMPD oxi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of COX2 (unknown origin) using arachidonic acid as substrate assessed as reduction in PGH2 conversion to PGG2 by measuring TMPD oxidation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member C2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibition of human recombinant AKR1C2 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member C3(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataIC50: 50nMAssay Description:the inhibitory potency of the individual compounds against the AKR1C isoforms was determined by monitoring the NADP+ dependent oxidation of S-tetralo...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member C2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataIC50: 2.75E+3nMAssay Description:the inhibitory potency of the individual compounds against the AKR1C isoforms was determined by monitoring the NADP+ dependent oxidation of S-tetralo...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member C3(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataIC50: 180nMAssay Description:the inhibitory potency of the individual compounds against the AKR1C isoforms was determined by monitoring the NADP+ dependent oxidation of S-tetralo...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Human)
The Trustees of The University of Pennsylvania

US Patent
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataIC50: 61nMAssay Description:The effect of the compounds on COX-1 activity was determined by a continuous colorimetric assay that monitored the oxidation of N, N, N, N-tetramethy...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataIC50: 900nMAssay Description:The effect of the compounds on COX-1 activity was determined by a continuous colorimetric assay that monitored the oxidation of N, N, N, N-tetramethy...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataEC50:  574nMAssay Description:Inhibition of Rac1 in human HeLa cells pretreated for 2 hrs followed by EGF stimulation for 2 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCell division control protein 42 homolog(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataEC50:  1.07E+3nMAssay Description:Inhibition of CDC42 in human HeLa cells pretreated for 2 hrs followed by EGF stimulation for 2 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataKi:  3.40E+6nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)