BDBM50527915 CHEMBL4441479

SMILES COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)c3cccnc3C)cccc12

InChI Key InChIKey=VVOKUJIAOSWPTI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50527915   

TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50527915(CHEMBL4441479)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK1 (866 to 1154 residues) expressed in insect cells using FITC-labeled C6-KKHTDDGYMPMSPGVA-NH...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50527915(CHEMBL4441479)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK2 (831 to 1132 residues) expressed in insect cells using 5FAM-labeled GEEPLYWSFPAKKK-NH2 pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed