BDBM50524994 CHEMBL4541964::US11401286, Example 142

SMILES OC(=O)Cc1ccc(Cc2cc(nc(c2)C(F)(F)F)-c2cccc(Cl)c2)cc1

InChI Key InChIKey=LTSUMTMGJHPGFX-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50524994   

TargetCytochrome P450 2C9(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 127nMAssay Description:Inhibition of recombinant human His6-tagged PDE4D2 expressed in baculovirus infected Sf9 insect cells using cAMP as substrate preincubated for 5 to 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of CYPC19 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [S133D](Human)
Tetra Discovery Partners

US Patent
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays are performed in 96-well plates in a total volume of 200 μl/well. Compounds are dissolved in dimethylsulfoxide (DMSO) and added to plates...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIsoform 7 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Tetra Discovery Partners

US Patent
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays are performed in 96-well plates in a total volume of 200 μl/well. Compounds are dissolved in dimethylsulfoxide (DMSO) and added to plates...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human PDE7D4More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 8nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human PDE4D7More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human PDE4D3More data for this Ligand-Target Pair
In DepthDetails
PubMed