BDBM50523657 CHEMBL4563402

SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(C(F)F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O

InChI Key InChIKey=HBGHQRGHFNTSDP-UHFFFAOYSA-N

Data  2 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50523657   

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523657(CHEMBL4563402)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50523657(CHEMBL4563402)
Affinity DataKd:  11nMAssay Description:Binding affinity to N-terminal 6xHis-tagged full length human PRMT5/MEP50 expressed in sf21 cells using S-Adenosyl-L-methionine as substrate assessed...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523657(CHEMBL4563402)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PRMT5 in human A427 cells assessed as reduction in sDMA level incubated for 72 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)