BDBM50522320 CHEMBL4454483

SMILES COc1ccccc1N1CCN(CC1)c1nc2CCCCc2c(=O)[nH]1

InChI Key InChIKey=OQNRYQMRIGYPGK-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50522320   

LigandPNGBDBM50522320(CHEMBL4454483)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50522320(CHEMBL4454483)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50522320(CHEMBL4454483)
Affinity DataIC50: 233nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50522320(CHEMBL4454483)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of human recombinant N-terminal TEV-cleavgae site-fused-FLAG/Polyhis-tagged PARP10 (2 to 583 residues) expressed in Escherichia coli asses...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50522320(CHEMBL4454483)
Affinity DataIC50: 2.23E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50522320(CHEMBL4454483)
Affinity DataIC50: 43nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50522320(CHEMBL4454483)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50522320(CHEMBL4454483)
Affinity DataIC50: 21nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50522320(CHEMBL4454483)
Affinity DataIC50: 19nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50522320(CHEMBL4454483)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50522320(CHEMBL4454483)
Affinity DataIC50: 2.23E+3nMAssay Description:Inhibition of PAPR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed