BDBM50511879 CHEMBL4466553

SMILES COc1cc(OC)c2c(c1)nc([nH]c2=O)-c1cc(C)c(OCCN2CCCC2)c(C)c1

InChI Key InChIKey=PQZDYFRDRHRZGF-UHFFFAOYSA-N

Data  6 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50511879   

TargetBromodomain-containing protein 4(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50511879(CHEMBL4466553)
Affinity DataIC50: 20nMAssay Description:Inhibition of biotinylated H4 peptide binding to recombinant N-terminal Hist-tagged BRD4 BD2 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50511879(CHEMBL4466553)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of biotinylated H4 peptide binding to recombinant N-terminal Hist-tagged BRD4 BD1 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 beta(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50511879(CHEMBL4466553)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of IL-1beta in mouse BMDM cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterleukin-17A(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50511879(CHEMBL4466553)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of IL-17 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50511879(CHEMBL4466553)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of BRD4 BD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50511879(CHEMBL4466553)
Affinity DataIC50: 20nMAssay Description:Inhibition of BRD4 BD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)