BDBM50503251 AG-221::Ag 221::CC-90007 Free Base::Enasidenib::US10946023, Compound 288
SMILES CC(C)(O)CNc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F
InChI Key InChIKey=DYLUUSLLRIQKOE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 50503251
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 319nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincub...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) expressed in human TF-1 cells assessed as inhibition of D2HG production incubated for 3 days by UHPL...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 2.65E+4nMAssay Description:Inhibition of wildtype IDH2 (unknown origin) using alpha-ketoglutarate as substrate incubated for 1 hrs in the presence of NADPH by absorbance based ...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 438nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) using alpha-ketoglutarate as substrate incubated for 1 hrs in the presence of NADPH by absorbance ba...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 179nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) using alpha-ketoglutarate as substrate incubated for 16 hrs in the presence of NADPH by absorbance b...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of wildtype IDH2 (unknown origin) in the presence of NADPH by fluorescence based analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) in the presence of NADPH by fluorescence based analysisMore data for this Ligand-Target Pair
Affinity DataKd: 1.17E+4nMAssay Description:Binding affinity to human recombinant IDH1 R132H mutant expressed in Escherichia coli BL21(DE3) pLysS cells assessed as dissociation constant by non-...More data for this Ligand-Target Pair
Affinity DataKd: 1.38E+4nMAssay Description:Binding affinity to human recombinant IDH1 expressed in Escherichia coli BL21(DE3) pLysS cells assessed as dissociation constant by non-denaturing ma...More data for this Ligand-Target Pair
Affinity DataKd: 1.20E+4nMAssay Description:Binding affinity to recombinant IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS cells assessed as dissociation const...More data for this Ligand-Target Pair
Affinity DataKd: 1.40E+4nMAssay Description:Binding affinity to recombinant wildtype IDH1 (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS cells assessed as dissociation constant ...More data for this Ligand-Target Pair
Affinity DataKd: >4.00E+5nMAssay Description:Binding affinity to recombinant IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS cells assessed as dissociation const...More data for this Ligand-Target Pair
Affinity DataKd: >4.00E+5nMAssay Description:Binding affinity to recombinant wildtype IDH1 (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS cells assessed as dissociation constant ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS cells using 2OG as substrate assessed as 2...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant wildtype IDH1 (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS cells using DL-isocitrste as substrate assesse...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of wild type IDH2 (unknown origin) assessed as reduction in NADPH production using sodium(D)-isocitrate and NADP as substrate preincubated...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of wild type IDH2 (unknown origin)More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 269nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincub...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 124nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincub...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincub...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:In the primary reaction, the reduction of α-KG acid to 2-HG is accompanied by a concomitant oxidation of NADPH to NADP. The amount of NADPH rema...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin)More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of wild type IDH2 (unknown origin)More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of wild type IDH1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin)More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.95E+3nMAssay Description:Inhibition of full length C-terminal His8 tagged IDH1 R132H mutant (1 to 414 residues) (unknown origin) homodimer expressed in Escherichia coli BE3 c...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 262nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 60 mins by by d...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 362nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) using alpha-KG as substrate after 60 mins in presence of NADPH by resazurin-based assayMore data for this Ligand-Target Pair