BDBM50503111 CHEMBL4528514::US11672785, Goodacre Compound 102::US20240043442, Example 5::US20240131013, Goodacre Compound 102
SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(OCCN2CC(CF)C2)cc1F
InChI Key InChIKey=YENNSFZGAPUOQB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50503111
Affinity DataIC50: 1nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 0.0794nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as downregulation of ER alpha receptor expression measured after 18 to 22 hrs by immuno...More data for this Ligand-Target Pair
Affinity DataIC50: 0.190nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.530nMAssay Description:Antagonist activity at estrogen receptor in human T47D cells incubated for 18 hrs by ultra high sensitivity luminescence reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.62nMAssay Description:Compounds were screened for their ability to displace a fluorescent labelled tracer ERβ ligand via time resolved fluorescent energy transfer usi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.62nMAssay Description:Compounds were screened for their ability to displace a fluorescent labelled tracer ERα ligand via time resolved fluorescent energy transfer usi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Compound activity was analyzed using celltiter-glo luminescent viability assay (Promega #G7572) in breast cancer cell line MCF-7. Cells grown in log ...More data for this Ligand-Target Pair