BDBM50502387 CHEMBL4458320
SMILES CCS(=O)(=O)c1ccc(cc1)C(NC(=O)Cc1ccccc1)C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
InChI Key InChIKey=YNDQSYNAWXKDSD-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50502387
Affinity DataIC50: 40nMAssay Description:Displacement of tritiated 2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from human N-(HN)6-GST-TCS-RORC LBD (258 ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Agonist activity at human His6-tcs-RORalpha LBD assessed as PGC1alpha peptide (130 to 154 residues) recruitment incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Displacement of tritiated 2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from mouse HN-AVI-GST-TCS-RORC (256 to 51...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inverse agonist activity at human biotinylated HN-Avi-MBPS-TCS-RORC2 (258 to 518 residues) assessed as recruitment of SRC-1-derived coactivator measu...More data for this Ligand-Target Pair