BindingDB BDBM50499634 CHEMBL3741589

BDBM50499634 CHEMBL3741589

SMILES OC(=O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C1

InChI Key InChIKey=WAAWETUDFSIYSD-UHFFFAOYSA-N

Data 127 IC50 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 129 hits for monomerid = 50499634

Calcium/calmodulin-dependent protein kinase type 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of CaMK1 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
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MAP/microtubule affinity-regulating kinase 3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of CTAK1 (unknown origin)More data for this Ligand-Target Pair

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MAP kinase-activated protein kinase 3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of MK3 (unknown origin)More data for this Ligand-Target Pair

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RAC-gamma serine/threonine-protein kinase(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of AKT3 (unknown origin)More data for this Ligand-Target Pair

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Sphingosine 1-phosphate receptor 1(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 362nMAssay Description:Displacement of [33P]S1P from S1P1 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair

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Sphingosine 1-phosphate receptor 5(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 6nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair

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Sphingosine 1-phosphate receptor 1(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 362nMAssay Description:Agonist activity at S1P1 receptor (unknown origin) expressed in CHO cell membranes after 30 mins by GTPgammaS binding based MFB methodMore data for this Ligand-Target Pair

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Sphingosine 1-phosphate receptor 5(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

EC50: 4.10nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by GTPgammaS ...More data for this Ligand-Target Pair

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RAC-alpha serine/threonine-protein kinase(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair

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ALK tyrosine kinase receptor(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair

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Serine/threonine-protein kinase BRSK1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of BRSK1 (unknown origin)More data for this Ligand-Target Pair

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Calcium/calmodulin-dependent protein kinase type II subunit delta(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of CaMK2delta (unknown origin)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of CDC2 (unknown origin)More data for this Ligand-Target Pair

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Cell division cycle 7-related protein kinase/Protein DBF4 homolog A(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of CDC7/DBF4 (unknown origin)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 2(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

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Serine/threonine-protein kinase Chk2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of CHK2 (unknown origin)More data for this Ligand-Target Pair

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Casein kinase I isoform delta(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of CK1delta (unknown origin)More data for this Ligand-Target Pair

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Casein kinase I isoform gamma-3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of CK1gamma3 (unknown origin)More data for this Ligand-Target Pair

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Casein kinase I isoform gamma-2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of CKgamma2 (unknown origin)More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair

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Receptor tyrosine-protein kinase erbB-2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of ERBB2 (unknown origin)More data for this Ligand-Target Pair

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Tyrosine-protein kinase Fer(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of FER (unknown origin)More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1/2/3/4(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of FGFR (unknown origin)More data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of FLT1 (unknown origin)More data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 3(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of FLT4 (unknown origin)More data for this Ligand-Target Pair

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Glycogen synthase kinase-3 alpha(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair

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Insulin-like growth factor 1 receptor(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair

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Insulin receptor(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair

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Interleukin-1 receptor-associated kinase 4(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair

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Tyrosine-protein kinase ITK/TSK(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair

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Tyrosine-protein kinase JAK2(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase kinase 5(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of KHS (unknown origin)More data for this Ligand-Target Pair

KEGG
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Mitogen-activated protein kinase kinase kinase kinase 2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of MAP4K2 (unknown origin)More data for this Ligand-Target Pair

KEGG
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Mitogen-activated protein kinase kinase kinase kinase 4(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of MAP4K4 (unknown origin)More data for this Ligand-Target Pair

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MAP kinase-activated protein kinase 2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of MAPK-APK2 (unknown origin)More data for this Ligand-Target Pair

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Maternal embryonic leucine zipper kinase(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of MELK (unknown origin)More data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair

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Serine/threonine-protein kinase 3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of MST2 (unknown origin)More data for this Ligand-Target Pair

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Serine/threonine-protein kinase Nek2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of NEK2 (unknown origin)More data for this Ligand-Target Pair

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Ribosomal protein S6 kinase beta-1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of P70S6K (unknown origin)More data for this Ligand-Target Pair

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Serine/threonine-protein kinase PAK 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair

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3-phosphoinositide-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair

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Protein kinase C delta type(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of PKCdelta (unknown origin)More data for this Ligand-Target Pair

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Protein kinase C zeta type(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of PKCzeta (unknown origin)More data for this Ligand-Target Pair

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Serine/threonine-protein kinase D2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of PKD2 (unknown origin)More data for this Ligand-Target Pair

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Serine/threonine-protein kinase N2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of PKN2 (unknown origin)More data for this Ligand-Target Pair

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Serine/threonine-protein kinase PLK3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of PLK3 (unknown origin)More data for this Ligand-Target Pair

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Serine/threonine-protein kinase PLK4(Human)
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Curated by ChEMBL

BDBM50499634(CHEMBL3741589)

IC50: 1.00E+4nMAssay Description:Inhibition of PLK4 (unknown origin)More data for this Ligand-Target Pair

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Displayed 1 to 50 (of 129 total ) | Next | Last >>

Filter my 129 hits

Targets 126▿
- Sphingosine 1-phosphate receptor 5 3
- Sphingosine 1-phosphate receptor 1 2
- Receptor tyrosine-protein kinase erbB-4 1
- Receptor tyrosine-protein kinase erbB-2 1
- Tyrosine-protein kinase FRK 1
- Hepatocyte growth factor receptor 1
- ALK tyrosine kinase receptor 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Glycogen synthase kinase-3 alpha 1
- Glycogen synthase kinase-3 beta 1
- Calcium/calmodulin-dependent protein kinase type 1 1
- Protein kinase C iota type 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Serine/threonine-protein kinase Nek4 1
- Calcium/calmodulin-dependent protein kinase type II subunit beta 1
- Serine/threonine-protein kinase Nek2 1
- MAP/microtubule affinity-regulating kinase 3 1
- Homeodomain-interacting protein kinase 4 1
- Serine/threonine-protein kinase PAK 1 1
- MAP kinase-interacting serine/threonine-protein kinase 2 1
- Serine/threonine-protein kinase PAK 4 1
- Tyrosine-protein kinase JAK3 1
- Tyrosine-protein kinase JAK2 1
- Proto-oncogene tyrosine-protein kinase receptor Ret 1
- Serine/threonine-protein kinase Sgk1 1
- Casein kinase I isoform gamma-3 1
- Casein kinase I isoform gamma-2 1
- Casein kinase I isoform gamma-1 1
- Ephrin type-A receptor 2 1
- Tyrosine-protein kinase BTK 1
- Tyrosine-protein kinase ITK/TSK 1
- Insulin-like growth factor 1 receptor 1
- Tyrosine-protein kinase Blk 1
- Epidermal growth factor receptor 1
- Homeodomain-interacting protein kinase 2 1
- Ribosomal protein S6 kinase beta-1 1
- Tyrosine-protein kinase Srms 1
- Casein kinase I isoform delta 1
- Tyrosine-protein kinase Lyn 1
- Cyclin-dependent kinase 2 1
- Lymphokine-activated killer T-cell-originated protein kinase 1
- Cyclin-dependent kinase 1 1
- MAP kinase-activated protein kinase 2 1
- MAP kinase-activated protein kinase 3 1
- MAP kinase-activated protein kinase 5 1
- Tyrosine-protein kinase Fer 1
- Serine/threonine-protein kinase D2 1
- Serine/threonine-protein kinase D3 1
- Calcium/calmodulin-dependent protein kinase type II subunit delta 1
- Death-associated protein kinase 3 1
- Proto-oncogene tyrosine-protein kinase ROS 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Fibroblast growth factor receptor 1/2/3/4 1
- Serine/threonine-protein kinase pim-3 1
- Serine/threonine-protein kinase pim-1 1
- Serine/threonine-protein kinase pim-2 1
- Serine/threonine-protein kinase DCLK2 1
- Serine/threonine-protein kinase TAO2 1
- Testis-specific serine/threonine-protein kinase 1 1
- Mitogen-activated protein kinase kinase kinase kinase 2 1
- Testis-specific serine/threonine-protein kinase 2 1
- Mast/stem cell growth factor receptor Kit 1
- Serine/threonine-protein kinase MRCK alpha 1
- Mitogen-activated protein kinase kinase kinase kinase 4 1
- Mitogen-activated protein kinase kinase kinase kinase 5 1
- Cyclin-dependent kinase 5 activator 1 1
- Interleukin-1 receptor-associated kinase 4 1
- RAC-gamma serine/threonine-protein kinase 1
- Interleukin-1 receptor-associated kinase 1 1
- RAC-alpha serine/threonine-protein kinase 1
- Megakaryocyte-associated tyrosine-protein kinase 1
- Rho-associated protein kinase 2 1
- Rho-associated protein kinase 1 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Tyrosine-protein kinase Fes/Fps 1
- BDNF/NT-3 growth factors receptor 1
- Mitogen-activated protein kinase 1 1
- Serine/threonine-protein kinase 3 1
- 3-phosphoinositide-dependent protein kinase 1 1
- Serine/threonine-protein kinase 17A 1
- Tyrosine-protein kinase Lck 1
- Protein kinase C delta type 1
- NT-3 growth factor receptor 1
- Mitogen-activated protein kinase 9 1
- Dual specificity protein kinase CLK4 1
- Dual specificity protein kinase CLK2 1
- High affinity nerve growth factor receptor 1
- Serine/threonine-protein kinase N2 1
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 1
- Potassium voltage-gated channel subfamily H member 2 1
- Mitogen-activated protein kinase 8 1
- Calcium/calmodulin-dependent protein kinase type IV 1
- Tyrosine-protein kinase SYK 1
- Ribosomal protein S6 kinase alpha-3 1
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1
- STE20-like serine/threonine-protein kinase 1
- Cell division cycle 7-related protein kinase/Protein DBF4 homolog A 1
- Aurora kinase B 1
- Vascular endothelial growth factor receptor 2 1
- Insulin receptor 1
- Vascular endothelial growth factor receptor 3 1
- Aurora kinase A 1
- Mitogen-activated protein kinase kinase kinase 20 1
- Fibroblast growth factor receptor 3 1
- Vascular endothelial growth factor receptor 1 1
- Serine/threonine-protein kinase PLK1 1
- Sphingosine 1-phosphate receptor 3 1
- Serine/threonine-protein kinase PLK3 1
- Serine/threonine-protein kinase PLK4 1
- Mitogen-activated protein kinase 13 1
- Mitogen-activated protein kinase 12 1
- Tyrosine-protein kinase receptor TYRO3 1
- RAC-beta serine/threonine-protein kinase 1
- Serine/threonine-protein kinase BRSK1 1
- Casein kinase I isoform alpha 1
- Protein kinase C gamma type 1
- Tyrosine-protein kinase Fyn 1
- Macrophage colony-stimulating factor 1 receptor 1
- Ribosomal protein S6 kinase alpha-5 1
- Maternal embryonic leucine zipper kinase 1
- Protein kinase C zeta type 1
- Serine/threonine-protein kinase Chk2 1
- Serine/threonine-protein kinase Chk1 1
- cAMP-dependent protein kinase catalytic subunit PRKX 1
- SRSF protein kinase 1 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 4 1
Publications 1▿
- J Med Chem 58: 9154-70 (2015) 129
Institutions 1▿
- Abbvie Bioresearch Center 129
Affinity: 4.1 to 7.7E+4 nM▿
- IC50 127
- EC50 2
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1