BDBM50468244 CHEMBL4284413

SMILES O=C(Nc1nccs1)C(N1Cc2ccccc2C1=O)c1ccccc1

InChI Key InChIKey=PWRVRDCBFYLYFU-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50468244   

TargetEpidermal growth factor receptor(Human)
R. C. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50468244(CHEMBL4284413)
Affinity DataIC50: 24nMAssay Description:Inhibition of human EGFR L858R mutant expressed in Sf9 cells in presence of 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
R. C. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50468244(CHEMBL4284413)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human wild type EGFR expressed in Sf9 cells in presence of 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
R. C. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50468244(CHEMBL4284413)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
R. C. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50468244(CHEMBL4284413)
Affinity DataIC50: 24nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
R. C. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50468244(CHEMBL4284413)
Affinity DataIC50: 24nMAssay Description:Inhibition of human GST-tagged EGFR L858R/T790M mutant expressed in Sf9 insect cells using ATP as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
R. C. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50468244(CHEMBL4284413)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human wild type EGFR expressed in Sf9 insect cells using ATP as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Mouse)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50468244(CHEMBL4284413)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type EGFR in mouse BaF3 cells assessed as cell growth inhibition measured after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
R. C. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50468244(CHEMBL4284413)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant in human NCI-H1975 cells assessed as cell growth inhibition measured after 72 hrs by CellTiter-Glo...More data for this Ligand-Target Pair
In DepthDetails
PubMed