BDBM50465543 CHEMBL4278778

SMILES CCn1cnc2n(Cc3ccc(CNS(=O)(=O)c4ccc5NC(=O)CCCc5c4)cc3)c(=O)[nH]c(=O)c12

InChI Key InChIKey=GUZDPSZLHQZPSV-UHFFFAOYSA-N

Data  2 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50465543   

TargetBromodomain-containing protein 4(Human)
Aix-Marseille University

Curated by ChEMBL
LigandPNGBDBM50465543(CHEMBL4278778)
Affinity DataIC50: 251nMAssay Description:Inhibition of TEV cleavage site-fused-GST tagged BRD4(BD1) (unknown origin) using SGRGK(Ac)CGK(Ac)-GLGK(Ac)GGAK(Ac)RHRKVG-peptide after 3 hrs by HTRF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Aix-Marseille University

Curated by ChEMBL
LigandPNGBDBM50465543(CHEMBL4278778)
Affinity DataIC50: 251nMAssay Description:Inhibition of TEV cleavage site-fused-GST tagged BRD4(BD1) (unknown origin) using SGRGK(Ac)CGK(Ac)-GLGK(Ac)GGAK(Ac)RHRKVG-peptide after 3 hrs by HTRF...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Aix-Marseille University

Curated by ChEMBL
LigandPNGBDBM50465543(CHEMBL4278778)
Affinity DataKd:  190nMAssay Description:Binding affinity to TEV cleavage site-fused-His-tagged BRD4(BD1) (unknown origin) by isothermal-titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)