BDBM50452245 Act-709478

SMILES FC(F)(F)C1(CC1)c1ccc(CC(=O)Nc2ccn(Cc3ccc(cn3)C#N)n2)cc1

InChI Key InChIKey=LSYANGLAZUZYFX-UHFFFAOYSA-N

Data  1 KI  19 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50452245   

TargetCytochrome P450 2D6(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 2.41E+3nMAssay Description:Inhibition of recombinant Cav1.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of recombinant Cav3.1 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Rat)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 13nMAssay Description:Inhibition of Cav3.2 in rat assessed as decrease in calcium flux preincubated for 3 mins followed by CaCl2 addition by Fluo-4-AM dye-based FLIPR assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A4(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of human CYP3A4 using testosterone as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2A6(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2A6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Mouse)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 40nMAssay Description:Inhibition of Cav3.2 in mouse assessed as decrease in calcium flux preincubated for 3 mins followed by CaCl2 addition by Fluo-4-AM dye-based FLIPR as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Rat)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 16nMAssay Description:Inhibition of Cav3.1 in rat assessed as decrease in calcium flux preincubated for 3 mins followed by CaCl2 addition by Fluo-4-AM dye-based FLIPR assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of human CYP2B6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of recombinant Cav3.3 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C8(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human CYP2C8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetT-type calcium channel alpha 1G subunit(Mouse)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of Cav3.1 in mouse assessed as decrease in calcium flux preincubated for 3 mins followed by CaCl2 addition by Fluo-4-AM dye-based FLIPR as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Rat)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of Cav3.3 in rat assessed as decrease in calcium flux preincubated for 3 mins followed by CaCl2 addition by Fluo-4-AM dye-based FLIPR assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452245(Act-709478)
Affinity DataKi:  20nMAssay Description:Binding activity to inactivated state of recombinant human Cav3.3 expressed in CHO cells assessed as inhibition of tail current amplitude by whole ce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed