BDBM50450704 CHEMBL560895::SNX-2112

SMILES CC1(C)Cc2c(c(nn2-c2ccc(C(N)=O)c(N[C@H]3CC[C@H](O)CC3)c2)C(F)(F)F)C(=O)C1

InChI Key InChIKey=ZFVRYNYOPQZKDG-UHFFFAOYSA-N

Data  9 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50450704   

TargetHeat shock protein HSP 90-alpha/90-beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 34nMAssay Description:Inhibition of FITC-geldanamycin binding to human His-tagged HSP90alpha N-terminal domain (1 to 236 residues) expressed in Escherichia coli BL21star (...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 2nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as Hsp70 induction after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 41nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as pERK degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 1nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as pS6 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as Her2 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndoplasmin(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataKd:  484nMAssay Description:Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataKd:  4nMAssay Description:Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) after 5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
The University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 4nMAssay Description:Inhibition of FITC-GDA binding to human HSP90-beta incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 6nMAssay Description:Inhibition of FITC-GDA binding to human HSP90-alpha incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndoplasmin(Dog)
The University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 484nMAssay Description:Inhibition of FITC-GDA binding to dog GRP94 incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein 75 kDa, mitochondrial(Human)
The University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 791nMAssay Description:Inhibition of FITC-GDA binding to human TRAP1 incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed