BDBM50446302 CHEMBL3109325
SMILES CCCN(Cc1ccccc1)Cc1ccc(NC(=O)Cc2ccc(cc2)S(=O)(=O)CC)cc1
InChI Key InChIKey=PWRYHBNVYOIZJC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50446302
Affinity DataEC50: 20nMAssay Description:Inverse agonist activity at human RoRc-LBD fusion protein with GST expressed in BL-21 (BL3) cells assessed as SRC1 coactivator peptide recruitmentMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 2.50E+4nMAssay Description:Inverse agonist activity at biotinylated human RORgammat LBD expressed in Escherichia coli BL21 assessed as inhibition of SRC1 recruitment after 1 hr...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Inverse agonist activity at biotinylated human RORgammat expressed in Escherichia coli BL21 assessed as effect on recruitment of SRC1/2 after 1 hr by...More data for this Ligand-Target Pair
Affinity DataEC50: 7.80nMAssay Description:Agonist activity at APC-labeled RORgammat LBD (unknown origin) incubated for 1 hr in presence of europium labeled co-activator SRC1 by dual FRET assa...More data for this Ligand-Target Pair
Affinity DataEC50: 99nMAssay Description:Agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as maximum activation incubated for 1 hr in presence of europium labeled co-a...More data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Agonist activity at human RORgammat LBD expressed in HEK293T cells assessed as increase in Gal4 reporter gene transcription measured after 16 to 20 h...More data for this Ligand-Target Pair