BDBM50444585 CHEMBL3099720::US9340549, 65

SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cnc(N)c(c1)-c1ncccn1

InChI Key InChIKey=BGDLETKJFQIBLX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50444585   

LigandPNGBDBM50444585(CHEMBL3099720 | US9340549, 65)
Affinity DataIC50: 49nMT: 2°CAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50444585(CHEMBL3099720 | US9340549, 65)
Affinity DataIC50: 25.9nMT: 2°CAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50444585(CHEMBL3099720 | US9340549, 65)
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50444585(CHEMBL3099720 | US9340549, 65)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed